BRIT has developed state-of-the-art methods and standardized procedures for the synthesis, purification and quality control /quality assurance of labelled compounds and biomolecules. As Carbon and Hydrogen are fundamental components of all organic compounds, they can be replaced with their isotopes (Carbon-14 and Other Isotopic labelled compound) without altering their chemical properties. These compounds can be detected and quantified with high sensitivity at nanomolar levels of concentration thus making them the favoured choice for biological research.

Tritium labelled compounds

Tritium labelled compounds are used as radiotracers in a wide range of studies such as in biochemistry, enzyme mechanisms, elucidation of organic reaction mechanisms and in environmental sciences for development of crop protection agents.

• Supply of wide range - amino acids, hormones, nucleic acids etc.
• Free of labile tritium
• Radiochemical purity >95 %
• Custom based synthesis offered

 

Sr.No.	Product Name	Product Code
1	Thymidine-methyl-T (Low sp.act.)	LCT 3
2	Thymidine-methyl-T (High sp.act.)	LCT 53
3	Tritiated water (Low sp. act.)	LCT 17
4	Tritiated water (High sp.act)	LCT 51
5	Uracil-5-T	LCT 30
6	Uridine-5-T	LCT 55
7	L-Leucine-T(G)	LCT 11
8	L-Phenylalanine-T(G)	LCT 13

Carbon-14 labelled compounds

Carbon-14 labelled compounds are indispensable tools in the assessment of novel pharmaceuticals using absorption, distribution, metabolism & excretion (ADME) studies in living beings and in enzymatic and sub-cellular in vitro research applications.

• Supply of wide range - amino acids, sugars, organophosphates, insecticides
• Radiochemical purity >95 %
• Custom based synthesis offered

 

Sr.No.	Product Name	Product Code
1	Acetic Anhydride-1-14C	LCC 51
2	L-Alanine-U-14C	LCC 153
3	Algal protein hydrolysate U-14C	LCC 111
4	L-Arginine-U-14C	LCC 154
5	L-Aspartic acid-U-14C	LCC 155
6	Benzoic acid-carboxyl-14C	LCC 6
7	Choline -methyl-14C chloride	LCC 195
8	2-Deoxy Glucose-14C (U) -Enquire	LCC 231
9	D-Fructose-U-14C	LCC 8
10	D- Glucosamine -14C (U) Hydrochloride	LCC 193
11	D-Glucose-U-14C	LCC 9
12	D-Glucose-1-14C	LCC 10
13	L-Glutamic acid-U-14C	LCC 156
14	DL-Glyceric acid-1-14C	LCC 189
15	Glycerol-1(3)- 14C	LCC 196
16	Glycine-14C(U)	LCC 121
17	Glycine-2-14C	LCC 12
18	Glycolic acid-1-14C	LCC 171
19	Guanine-8-14C hydrochloride - Enquire	LCC 14
20	L-Isoleucine-U-14C	LCC 124
21	L-Lactic acid-U-14C	LCC 139
22	L-Leucine-U-14C	LCC 157
23	L-Lysine-U-14C	LCC 158
24	L-Malic acid-U-14C	LCC 169
25	D-Mannose-U-14C	LCC 170
26	Oxalic acid-1-14C	LCC 214
27	Palmitic acid-1-14C	LCC 21
28	L-Phenylalanine-U-14C	LCC 159
29	Potassium cyanide-14C	LCC 29
30	L-Serine-U-14C	LCC 160
31	Sodium acetate-1-14C	LCC 32
32	Sodium acetate-2-14C	LCC 33
33	Sodium acetate-1,2-14C	LCC 34
34	Sodium bicarbonate-14C	LCC 35
35	Sodium bicarbonate-14C ( 5 Ci/ml/ ampoule )	LCC 162
36	Sodium carbonate-14C	LCC 37
37	D-Sucrose-U-14C	LCC 164
38	Urea-14C (solid)	LCC 49

Special Illuminators

‘Special Illuminators’ are non-electrical light sources used for night-illumination of various gadgets. These are fabricated in the form of sealed glass tubes, internally coated with suitable phosphor material and filled with suitable radioisotope in gaseous form’. The glass tubes are generally made of borosilicate glass. They are having wide variety of shapes and sizes, limited only by glass-working techniques. These light sources have a maintenance-free useful life of 10-12 years.

They find wide range of applications in illumination of various military gadgets where reliability is absolutely essential and also used in commercial and industrial buildings in the form of warning signs, way indicators etc.

Sr.No.	Type	Radioactivity(Ci)	Light Output in microlambards	Shape	Outer Diameter(OD)	Length
1	SI-6	0.3	580	Curved	4 mm	26 mm
2	SI-7	0.12	500	Straight	3 mm	10 mm
3	SI-8	0.3	200	Straight	3 mm	25 mm
4	SI-11	0.3	520	Curved	4 mm	25 mm
5	SI-12	0.37	550	Curved	4 mm	29 mm
6	SI-13	0.14	675	Curved	3 mm	13 mm
7	SI-15	0.4	450	Curved	6 mm	20 mm
8	SI-15A	0.4	450	Curved	5 mm	20 mm
9	SI-17	0.37	575	Curved	4 mm	39 mm
10	SI-18	1.5	1000	Straight	8 mm	50 mm
11	SI-21	0.87	1000	Straight	6 mm	41 mm
12	SI-23	1.00	1000	Button	22 mm	14 mm
13	SI-26	0.2	440	Straight	4 mm	20 mm
14	SI-27	0.175	500	Curved	3 mm	18 mm

 

Deuterated NMR solvents

BRIT offers a wide range of deuterated NMR solvents which serve as versatile tools for discerning research in the field of NMR spectroscopy.

• Excellent chemical purity
• low residual water
• highest isotopic enrichment (99+% of the protons are replaced with deuterium)
• Various denominations available in glass ampoules /bottles

 

Sr.No.	Product Description	Product Code
1	Acetone-d6 (>99.8 atom % D)	LCD-1
2	Acetonitrile-d3 (>99.8 atom % D)	LCD-2
3	Benzene-d6 (>99.8 atom %D)	LCD-3
4	Chloroform-d (>99.8 atom % D)	LCD-4
5	Dimethyl sulfoxide-d6 (>99.8 atom % D)	LCD-6
6	Deuterium Oxide (Heavy water) (>99.8 atom % D)	DW-110
7	Deuterium Oxide (Heavy water) (>99.8 atom % D)	DW-10

 

Sulpur-35 labelled amino acids

35S-amino acids are widely used as radiotracers in protein synthesis studies.

BRIT offers various formulations of sulphur-35 radiolabeled amino acids which can be used in a variety of studies including metabolic labelling, cell labelling, protein labelling, protein degradation and pulse-chase analysis.

Sr.No.	Product Code	Product name	Formulation
1	LCS-1	L-35S-methionine	Aqueous solution containing 0.1% beta-mercaptoethanol and 20 mM potassium acetate
2	LCS-2	L-35S-methionine	Aqueous solution containing 0.1% beta-mercaptoethanol
3	LCS-3	L-35S-cysteine	Aqueous solution containing 5 mM DTT
4	LCS-7	35S-Elegmix	70% methionine and 30% cysteine in (in 0.1% beta-mercaptoethanol and 20 mM potassium acetate solution)
5	LCS-8	35S in vivo Pro Twinlabel mix	Mixture of L-[35S] methionine70%  + L-[35S] cysteine 25% + other L-[35S] labelled amino acid derivatives 5% in 50 mM tricine solution.