Labelled Compounds

BRIT has developed state-of-the-art methods and standardized procedures for the synthesis, purification and quality control /quality assurance of labelled compounds and biomolecules. As Carbon and Hydrogen are fundamental components of all organic compounds, they can be replaced with their isotopes (Carbon-14 and Tritium) without altering their chemical properties. These compounds can be detected and quantified with high sensitivity at nanomolar levels of concentration thus making them the favoured choice for biological research.

Tritium labelled compounds

Tritium labelled compounds are used as radiotracers in a wide range of studies such as in biochemistry, enzyme mechanisms, elucidation of organic reaction mechanisms and in environmental sciences for development of crop protection agents.

  • Supply of wide range - amino acids, hormones, nucleic acids etc.
  • Free of labile tritium
  • Radiochemical purity >95 %
  • Custom based synthesis offered
 
Sr.No. Product Name Product Code
1 Thymidine-methyl-T (Low sp.act.) LCT 3
2 Thymidine-methyl-T (High sp.act.) LCT 53
3 Tritiated water (Low sp. act.) LCT 17
4 Tritiated water (High sp.act) LCT 51
5 Uracil-5-T LCT 30
6 Uridine-5-T LCT 55
7 L-Leucine-T(G) LCT 11
8 L-Phenylalanine-T(G) LCT 13
Carbon-14 labelled compounds

Carbon-14 labelled compounds are indispensable tools in the assessment of novel pharmaceuticals using absorption, distribution, metabolism & excretion (ADME) studies in living beings and in enzymatic and sub-cellular in vitro research applications.

  • Supply of wide range - amino acids, sugars, organophosphates, insecticides
  • Radiochemical purity >95 %
  • Custom based synthesis offered
 
Sr.No. Product Name Product Code
1 Acetic Anhydride-1-14C LCC 51
2 L-Alanine-U-14C LCC 153
3 Algal protein hydrolysate U-14C LCC 111
4 L-Arginine-U-14C LCC 154
5 L-Aspartic acid-U-14C LCC 155
6 Benzoic acid-carboxyl-14C LCC 6
7 Choline -methyl-14C chloride LCC 195
8 2-Deoxy Glucose-14C (U) -Enquire LCC 231
9 D-Fructose-U-14C LCC 8
10 D- Glucosamine -14C (U) Hydrochloride LCC 193
11 D-Glucose-U-14C LCC 9
12 D-Glucose-1-14C LCC 10
13 L-Glutamic acid-U-14C LCC 156
14 DL-Glyceric acid-1-14C LCC 189
15 Glycerol-1(3)- 14C LCC 196
16 Glycine-14C(U) LCC 121
17 Glycine-2-14C LCC 12
18 Glycolic acid-1-14C LCC 171
19 Guanine-8-14C hydrochloride - Enquire LCC 14
20 L-Isoleucine-U-14C LCC 124
21 L-Lactic acid-U-14C LCC 139
22 L-Leucine-U-14C LCC 157
23 L-Lysine-U-14C LCC 158
24 L-Malic acid-U-14C LCC 169
25 D-Mannose-U-14C LCC 170
26 Oxalic acid-1-14C LCC 214
27 Palmitic acid-1-14C LCC 21
28 L-Phenylalanine-U-14C LCC 159
29 Potassium cyanide-14C LCC 29
30 L-Serine-U-14C LCC 160
31 Sodium acetate-1-14C LCC 32
32 Sodium acetate-2-14C LCC 33
33 Sodium acetate-1,2-14C LCC 34
34 Sodium bicarbonate-14C LCC 35
35 Sodium bicarbonate-14C ( 5 Ci/ml/ ampoule ) LCC 162
36 Sodium carbonate-14C LCC 37
37 D-Sucrose-U-14C LCC 164
38 Urea-14C (solid) LCC 49
Tritium filled light sources

Tritium Filled Light Sources are non-electrical light sources used for night-illumination of various gadgets. These are fabricated in the form of sealed glass tubes, internally coated with suitable phosphor material and filled with tritium gas. The glass tubes are generally made of borosilicate glass. They may have a wide variety of shapes and sizes, limited only by glass-working techniques. These light sources have a maintenance free useful life of 10-12 years.

They find wide range of applications in illumination of various military gadgets where reliability is absolutely essential and also in commercial and industrial buildings in the form of warning signs, way indicators etc.

Sr.No. Type Radioactivity(Ci) Light Output in microlambards Shape Outer Diameter(OD) Length
1 TFS-6 0.3 580 Curved 4 mm 26 mm
2 TFS-7 0.12 500 Straight 3 mm 10 mm
3 TFS-8 0.3 200 Straight 3 mm 25 mm
4 TFS-11 0.3 520 Curved 4 mm 25 mm
5 TFS-12 0.37 550 Curved 4 mm 29 mm
6 TFS-13 0.14 675 Curved 3 mm 13 mm
7 TFS-15 0.4 450 Curved 6 mm 20 mm
8 TFS-15A 0.4 450 Curved 5 mm 20 mm
9 TFS-17 0.37 575 Curved 4 mm 39 mm
10 TFS-18 1.5 1000 Straight 8 mm 50 mm
11 TFS-21 0.87 1000 Straight 6 mm 41 mm
12 TFS-23 1.00 1000 Button 22 mm 14 mm
13 TFS-26 0.2 440 Straight 4 mm 20 mm
14 TFS-27 0.175 500 Curved 3 mm 18 mm
 
Deuterated NMR solvents

BRIT offers a wide range of deuterated NMR solvents which serve as versatile tools for discerning research in the field of NMR spectroscopy.

  • Excellent chemical purity
  • low residual water
  • highest isotopic enrichment (99+% of the protons are replaced with deuterium)
  • Various denominations available in glass ampoules /bottles
 
Sr.No. Product Description Product Code
1 Acetone-d6 (>99.8 atom % D) LCD-1
2 Acetonitrile-d3 (>99.8 atom % D) LCD-2
3 Benzene-d6 (>99.8 atom %D) LCD-3
4 Chloroform-d (>99.8 atom % D) LCD-4
5 Dimethyl sulfoxide-d6 (>99.8 atom % D) LCD-6
6 Deuterium Oxide (Heavy water) (>99.8 atom % D) DW-110
7 Deuterium Oxide (Heavy water) (>99.8 atom % D) DW-10
 
Sulpur-35 labelled amino acids

35S-amino acids are widely used as radiotracers in protein synthesis studies.

BRIT offers various formulations of sulphur-35 radiolabeled amino acids which can be used in a variety of studies including metabolic labelling, cell labelling, protein labelling, protein degradation and pulse-chase analysis.

Sr.No. Product Code Product name Formulation
1 LCS-1 L-35S-methionine Aqueous solution containing 0.1% beta-mercaptoethanol and 20 mM potassium acetate
2 LCS-2 L-35S-methionine Aqueous solution containing 0.1% beta-mercaptoethanol
3 LCS-3 L-35S-cysteine Aqueous solution containing 5 mM DTT
4 LCS-7 35S-Elegmix 70% methionine and 30% cysteine in (in 0.1% beta-mercaptoethanol and 20 mM potassium acetate solution)
5 LCS-8 35S in vivo Pro Twinlabel mix Mixture of L-[35S] methionine70%  + L-[35S] cysteine 25% + other L-[35S] labelled amino acid derivatives 5% in 50 mM tricine solution.

Contact :

Jacob Sebastian

      Senior Manager, Teletherapy and Open Sources Board of Radiation & Isotope Technology

Project House, V.N. Purav Marg, Anushakti Nagar, Mumbai 400 094  

9869454140 / (022)2556 5535 / 2788 7702

jacob[at]britatom[dot]gov[dot]in